Sesquiterpene polyol esters from the leaves of Maytenus macrocarpa

The aerial parts of Maytenus macrocarpa yielded three new β- dihydroagarofuran sesquiterpene polyol esters. Their structures were elucidated by spectroscopic analyses including 2D NMR techniques as 6β,8β,15-triacetoxy-1α,9α-dibenzoyloxy-4β-hydroxy-β-dihydroagarofuran (1); 1α,6β,8β,15-tetraacetoxy-9α-benzoyloxy-4β-hydroxy-β- dihydroagarofuran (2) and (1S,4S,6R,7R,8R,9R)-1,6,15-triacetoxy-8,9- dibenzoyloxy-4-hydroxy-β-dihydroagarofuran (3). Compounds 1 and 2 showed marginal antitumor activity against four cell lines.