New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania

Paulino Delgado-Méndez; Nora Herrera; Haydee Chávez; Ana Estévez-Braun; Ángel G. Ravelo; Fernando Cortes; Santiago Castanys; Francisco Gamarro

doi:10.1016/j.bmc.2007.10.071

New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania

Paulino Delgado-Méndez, Nora Herrera, Haydee Chávez, Ana Estévez-Braun, Ángel G. Ravelo, Fernando Cortes, Santiago Castanys, Francisco Gamarro

FARMACIA Y BIOQUIMICA

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

30 Citas (Scopus)

Resumen

Two new sesquiterpenes (1-2) and one new lupane triterpene (3) have been isolated from the roots of Maytenus apurimacensis. The novel β-dihydroagarofurans are the first sesquiterpenes with a basic polyhydroxy skeleton of 15-deoxyalatol and 4,15-dideoxyalatol that show high MDR reversing activity in the protozoan parasite Leishmania tropica.

Idioma original	Inglés
Páginas (desde-hasta)	1425-1430
Número de páginas	6
Publicación	Bioorganic and Medicinal Chemistry
Volumen	16
N.º	3
DOI	https://doi.org/10.1016/j.bmc.2007.10.071
Estado	Publicada - 1 feb. 2008

Nota bibliográfica

Funding Information:
This work has been supported by the MCYT (SAF-2003-04200-C02-01, Project SAF2006-66720,) by ICIC (Instituto Canario de Investigación del Cáncer), by RICET Project RD06/0021/0002 and by Plan Andaluz de Investigación (Cod. CVI-130). We also thank to Dr. Trujillo-Vásquez for carrying out the CD spectra. P.D.M. thanks the support of the Universidad de Los Andes Sabbatical Program.

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10.1016/j.bmc.2007.10.071

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title = "New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania",

abstract = "Two new sesquiterpenes (1-2) and one new lupane triterpene (3) have been isolated from the roots of Maytenus apurimacensis. The novel β-dihydroagarofurans are the first sesquiterpenes with a basic polyhydroxy skeleton of 15-deoxyalatol and 4,15-dideoxyalatol that show high MDR reversing activity in the protozoan parasite Leishmania tropica.",

keywords = "Celastraceae, Dihydro-β-agarofuran sesquiterpenes, Leishmania, Lupanes, MDR, Maytenus, Terpenoids",

author = "Paulino Delgado-M{\'e}ndez and Nora Herrera and Haydee Ch{\'a}vez and Ana Est{\'e}vez-Braun and Ravelo, {{\'A}ngel G.} and Fernando Cortes and Santiago Castanys and Francisco Gamarro",

note = "Funding Information: This work has been supported by the MCYT (SAF-2003-04200-C02-01, Project SAF2006-66720,) by ICIC (Instituto Canario de Investigaci{\'o}n del C{\'a}ncer), by RICET Project RD06/0021/0002 and by Plan Andaluz de Investigaci{\'o}n (Cod. CVI-130). We also thank to Dr. Trujillo-V{\'a}squez for carrying out the CD spectra. P.D.M. thanks the support of the Universidad de Los Andes Sabbatical Program.",

year = "2008",

month = feb,

day = "1",

doi = "10.1016/j.bmc.2007.10.071",

language = "Ingl{\'e}s",

volume = "16",

pages = "1425--1430",

journal = "Bioorganic and Medicinal Chemistry",

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T1 - New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania

AU - Delgado-Méndez, Paulino

AU - Herrera, Nora

AU - Chávez, Haydee

AU - Estévez-Braun, Ana

AU - Ravelo, Ángel G.

AU - Cortes, Fernando

AU - Castanys, Santiago

AU - Gamarro, Francisco

N1 - Funding Information: This work has been supported by the MCYT (SAF-2003-04200-C02-01, Project SAF2006-66720,) by ICIC (Instituto Canario de Investigación del Cáncer), by RICET Project RD06/0021/0002 and by Plan Andaluz de Investigación (Cod. CVI-130). We also thank to Dr. Trujillo-Vásquez for carrying out the CD spectra. P.D.M. thanks the support of the Universidad de Los Andes Sabbatical Program.

PY - 2008/2/1

Y1 - 2008/2/1

N2 - Two new sesquiterpenes (1-2) and one new lupane triterpene (3) have been isolated from the roots of Maytenus apurimacensis. The novel β-dihydroagarofurans are the first sesquiterpenes with a basic polyhydroxy skeleton of 15-deoxyalatol and 4,15-dideoxyalatol that show high MDR reversing activity in the protozoan parasite Leishmania tropica.

AB - Two new sesquiterpenes (1-2) and one new lupane triterpene (3) have been isolated from the roots of Maytenus apurimacensis. The novel β-dihydroagarofurans are the first sesquiterpenes with a basic polyhydroxy skeleton of 15-deoxyalatol and 4,15-dideoxyalatol that show high MDR reversing activity in the protozoan parasite Leishmania tropica.

KW - Celastraceae

KW - Dihydro-β-agarofuran sesquiterpenes

KW - Leishmania

KW - Lupanes

KW - MDR

KW - Maytenus

KW - Terpenoids

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U2 - 10.1016/j.bmc.2007.10.071

DO - 10.1016/j.bmc.2007.10.071

M3 - Artículo

C2 - 18035546

AN - SCOPUS:38849125592

SN - 0968-0896

VL - 16

SP - 1425

EP - 1430

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

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ER -

New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania

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