Two new sesquiterpenes (1-2) and one new lupane triterpene (3) have been isolated from the roots of Maytenus apurimacensis. The novel β-dihydroagarofurans are the first sesquiterpenes with a basic polyhydroxy skeleton of 15-deoxyalatol and 4,15-dideoxyalatol that show high MDR reversing activity in the protozoan parasite Leishmania tropica.
Nota bibliográficaFunding Information:
This work has been supported by the MCYT (SAF-2003-04200-C02-01, Project SAF2006-66720,) by ICIC (Instituto Canario de Investigación del Cáncer), by RICET Project RD06/0021/0002 and by Plan Andaluz de Investigación (Cod. CVI-130). We also thank to Dr. Trujillo-Vásquez for carrying out the CD spectra. P.D.M. thanks the support of the Universidad de Los Andes Sabbatical Program.