Macrocarpins A-D, new cytotoxic nor-triterpenes from Maytenus macrocarpa

Haydee Chávez; Gladis Rodríguez; Ana Estévez-Braun; Ángel G. Ravelo; Rafael Estévez-Reyes; Antonio G. González; Jose L. Fdez-Puente; Dolores García-Grávalos

doi:10.1016/S0960-894X(00)00082-2

Macrocarpins A-D, new cytotoxic nor-triterpenes from Maytenus macrocarpa

Haydee Chávez, Gladis Rodríguez, Ana Estévez-Braun, Ángel G. Ravelo, Rafael Estévez-Reyes, Antonio G. González, Jose L. Fdez-Puente, Dolores García-Grávalos

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24 Citas (Scopus)

Resumen

Macrocarpins A (1), B (2), C (3) and D (4), four new nor-triterpenes, have been isolated from the roots of Maytenus macrocarpa. The structures were established by spectroscopic examinations. Natural compounds 1, 2, 4 and the acetyl derivative 1a are cytotoxic against four tumoral cell lines with IC₅₀ values ranging between 0.4 and 5.2 μM. (C) 2000 Elsevier Science Ltd. All rights reserved.

Idioma original	Inglés
Páginas (desde-hasta)	759-762
Número de páginas	4
Publicación	Bioorganic and Medicinal Chemistry Letters
Volumen	10
N.º	8
DOI	https://doi.org/10.1016/S0960-894X(00)00082-2
Estado	Publicada - abr. 2000
Publicado de forma externa	Sí

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Funding Information:
This work has been partly funded by the Spanish DGES (projects PB 96-1033 and PB 96-10339, by the Gobierno Autónomo de Canarias, and by the Instituto Tecnológico de Canarias. H. Chávez thanks the Agencia Española de Cooperación Internacional for a MUTIS grant. Thanks are also due to Professor L. Ruı́z for gathering the plant.

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@article{88824b337e244609a92b4b80bce3851b,

title = "Macrocarpins A-D, new cytotoxic nor-triterpenes from Maytenus macrocarpa",

abstract = "Macrocarpins A (1), B (2), C (3) and D (4), four new nor-triterpenes, have been isolated from the roots of Maytenus macrocarpa. The structures were established by spectroscopic examinations. Natural compounds 1, 2, 4 and the acetyl derivative 1a are cytotoxic against four tumoral cell lines with IC50 values ranging between 0.4 and 5.2 μM. (C) 2000 Elsevier Science Ltd. All rights reserved.",

author = "Haydee Ch{\'a}vez and Gladis Rodr{\'i}guez and Ana Est{\'e}vez-Braun and Ravelo, {{\'A}ngel G.} and Rafael Est{\'e}vez-Reyes and Gonz{\'a}lez, {Antonio G.} and Fdez-Puente, {Jose L.} and Dolores Garc{\'i}a-Gr{\'a}valos",

note = "Funding Information: This work has been partly funded by the Spanish DGES (projects PB 96-1033 and PB 96-10339, by the Gobierno Aut{\'o}nomo de Canarias, and by the Instituto Tecnol{\'o}gico de Canarias. H. Ch{\'a}vez thanks the Agencia Espa{\~n}ola de Cooperaci{\'o}n Internacional for a MUTIS grant. Thanks are also due to Professor L. Ru{\'ı}z for gathering the plant.",

year = "2000",

month = apr,

doi = "10.1016/S0960-894X(00)00082-2",

language = "Ingl{\'e}s",

volume = "10",

pages = "759--762",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

number = "8",

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TY - JOUR

T1 - Macrocarpins A-D, new cytotoxic nor-triterpenes from Maytenus macrocarpa

AU - Chávez, Haydee

AU - Rodríguez, Gladis

AU - Estévez-Braun, Ana

AU - Ravelo, Ángel G.

AU - Estévez-Reyes, Rafael

AU - González, Antonio G.

AU - Fdez-Puente, Jose L.

AU - García-Grávalos, Dolores

N1 - Funding Information: This work has been partly funded by the Spanish DGES (projects PB 96-1033 and PB 96-10339, by the Gobierno Autónomo de Canarias, and by the Instituto Tecnológico de Canarias. H. Chávez thanks the Agencia Española de Cooperación Internacional for a MUTIS grant. Thanks are also due to Professor L. Ruı́z for gathering the plant.

PY - 2000/4

Y1 - 2000/4

N2 - Macrocarpins A (1), B (2), C (3) and D (4), four new nor-triterpenes, have been isolated from the roots of Maytenus macrocarpa. The structures were established by spectroscopic examinations. Natural compounds 1, 2, 4 and the acetyl derivative 1a are cytotoxic against four tumoral cell lines with IC50 values ranging between 0.4 and 5.2 μM. (C) 2000 Elsevier Science Ltd. All rights reserved.

AB - Macrocarpins A (1), B (2), C (3) and D (4), four new nor-triterpenes, have been isolated from the roots of Maytenus macrocarpa. The structures were established by spectroscopic examinations. Natural compounds 1, 2, 4 and the acetyl derivative 1a are cytotoxic against four tumoral cell lines with IC50 values ranging between 0.4 and 5.2 μM. (C) 2000 Elsevier Science Ltd. All rights reserved.

UR - http://www.scopus.com/inward/record.url?scp=0242689810&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(00)00082-2

DO - 10.1016/S0960-894X(00)00082-2

M3 - Artículo

C2 - 10782680

AN - SCOPUS:0242689810

SN - 0960-894X

VL - 10

SP - 759

EP - 762

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 8

ER -

Macrocarpins A-D, new cytotoxic nor-triterpenes from Maytenus macrocarpa

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