Drug susceptibility testing and synergistic antibacterial activity of curcumin with antibiotics against enterotoxigenic Escherichia coli

Rangel Castañeda Itzia Azucena; Cruz Lozano José Roberto; Zermeño Ruiz Martin; Cortes Zarate Rafael; Hernández Hernández Leonardo; Tapia Pastrana Gabriela; Castillo Romero Araceli

doi:10.3390/antibiotics8020043

Drug susceptibility testing and synergistic antibacterial activity of curcumin with antibiotics against enterotoxigenic Escherichia coli

Rangel Castañeda Itzia Azucena, Cruz Lozano José Roberto, Zermeño Ruiz Martin, Cortes Zarate Rafael, Hernández Hernández Leonardo, Tapia Pastrana Gabriela, Castillo Romero Araceli

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

36 Citas (Scopus)

Resumen

Aim: This study investigated the susceptibility of Enterotoxigenic Escherichia coli to curcumin, as well as its synergistic effect with 12 antimicrobial drugs.Methods and Results: Our study shows that curcumin did not affect bacterial growth. The antimicrobial susceptibility of curcumin and antibiotic synergy were identified using disc diffusion on Mueller-Hinton agar. The strain of Enterotoxigenic Escherichia coli used was resistant to Ampicillin, Amoxicillin/Clavulanic acid, Ampicillin/Sulbactam, Ciprofloxacin, and Cefazolin. There was synergy between curcumin and the majority of antibiotics tested. Maximum synergy was observed with combinations of 330 μg/mL curcumin and Ceftazidime, followed by Cefotaxime, Amoxicillin/Clavulanic acid, Ampicillin, Aztreonam, Trimethoprim, Ciprofloxacin, Ceftriaxone, Cefazolin, Tetracycline, and Imipenem. Conclusion: Our findings indicated that curcumin might be useful as a combinatorial strategy to combat the antibiotic resistance of Enterotoxigenic Escherichia coli.

Idioma original	Inglés
Número de artículo	43
Publicación	Antibiotics
Volumen	8
N.º	2
DOI	https://doi.org/10.3390/antibiotics8020043
Estado	Publicada - jun. 2019
Publicado de forma externa	Sí

Nota bibliográfica

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Acceder al documento

10.3390/antibiotics8020043

Citar esto

@article{29a01728da984737a96dd8fd42061d2f,

title = "Drug susceptibility testing and synergistic antibacterial activity of curcumin with antibiotics against enterotoxigenic Escherichia coli",

abstract = "Aim: This study investigated the susceptibility of Enterotoxigenic Escherichia coli to curcumin, as well as its synergistic effect with 12 antimicrobial drugs.Methods and Results: Our study shows that curcumin did not affect bacterial growth. The antimicrobial susceptibility of curcumin and antibiotic synergy were identified using disc diffusion on Mueller-Hinton agar. The strain of Enterotoxigenic Escherichia coli used was resistant to Ampicillin, Amoxicillin/Clavulanic acid, Ampicillin/Sulbactam, Ciprofloxacin, and Cefazolin. There was synergy between curcumin and the majority of antibiotics tested. Maximum synergy was observed with combinations of 330 μg/mL curcumin and Ceftazidime, followed by Cefotaxime, Amoxicillin/Clavulanic acid, Ampicillin, Aztreonam, Trimethoprim, Ciprofloxacin, Ceftriaxone, Cefazolin, Tetracycline, and Imipenem. Conclusion: Our findings indicated that curcumin might be useful as a combinatorial strategy to combat the antibiotic resistance of Enterotoxigenic Escherichia coli.",

keywords = "Antibacterial, Antibiotics, Curcumin, Escherichia coli, Synergism",

author = "Azucena, {Rangel Casta{\~n}eda Itzia} and Roberto, {Cruz Lozano Jos{\'e}} and Martin, {Zerme{\~n}o Ruiz} and Rafael, {Cortes Zarate} and Leonardo, {Hern{\'a}ndez Hern{\'a}ndez} and Gabriela, {Tapia Pastrana} and Araceli, {Castillo Romero}",

note = "Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2019",

month = jun,

doi = "10.3390/antibiotics8020043",

language = "Ingl{\'e}s",

volume = "8",

journal = "Antibiotics",

issn = "2079-6382",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "2",

}

TY - JOUR

T1 - Drug susceptibility testing and synergistic antibacterial activity of curcumin with antibiotics against enterotoxigenic Escherichia coli

AU - Azucena, Rangel Castañeda Itzia

AU - Roberto, Cruz Lozano José

AU - Martin, Zermeño Ruiz

AU - Rafael, Cortes Zarate

AU - Leonardo, Hernández Hernández

AU - Gabriela, Tapia Pastrana

AU - Araceli, Castillo Romero

PY - 2019/6

Y1 - 2019/6

N2 - Aim: This study investigated the susceptibility of Enterotoxigenic Escherichia coli to curcumin, as well as its synergistic effect with 12 antimicrobial drugs.Methods and Results: Our study shows that curcumin did not affect bacterial growth. The antimicrobial susceptibility of curcumin and antibiotic synergy were identified using disc diffusion on Mueller-Hinton agar. The strain of Enterotoxigenic Escherichia coli used was resistant to Ampicillin, Amoxicillin/Clavulanic acid, Ampicillin/Sulbactam, Ciprofloxacin, and Cefazolin. There was synergy between curcumin and the majority of antibiotics tested. Maximum synergy was observed with combinations of 330 μg/mL curcumin and Ceftazidime, followed by Cefotaxime, Amoxicillin/Clavulanic acid, Ampicillin, Aztreonam, Trimethoprim, Ciprofloxacin, Ceftriaxone, Cefazolin, Tetracycline, and Imipenem. Conclusion: Our findings indicated that curcumin might be useful as a combinatorial strategy to combat the antibiotic resistance of Enterotoxigenic Escherichia coli.

AB - Aim: This study investigated the susceptibility of Enterotoxigenic Escherichia coli to curcumin, as well as its synergistic effect with 12 antimicrobial drugs.Methods and Results: Our study shows that curcumin did not affect bacterial growth. The antimicrobial susceptibility of curcumin and antibiotic synergy were identified using disc diffusion on Mueller-Hinton agar. The strain of Enterotoxigenic Escherichia coli used was resistant to Ampicillin, Amoxicillin/Clavulanic acid, Ampicillin/Sulbactam, Ciprofloxacin, and Cefazolin. There was synergy between curcumin and the majority of antibiotics tested. Maximum synergy was observed with combinations of 330 μg/mL curcumin and Ceftazidime, followed by Cefotaxime, Amoxicillin/Clavulanic acid, Ampicillin, Aztreonam, Trimethoprim, Ciprofloxacin, Ceftriaxone, Cefazolin, Tetracycline, and Imipenem. Conclusion: Our findings indicated that curcumin might be useful as a combinatorial strategy to combat the antibiotic resistance of Enterotoxigenic Escherichia coli.

KW - Antibacterial

KW - Antibiotics

KW - Curcumin

KW - Escherichia coli

KW - Synergism

UR - http://www.scopus.com/inward/record.url?scp=85066976647&partnerID=8YFLogxK

U2 - 10.3390/antibiotics8020043

DO - 10.3390/antibiotics8020043

M3 - Artículo

AN - SCOPUS:85066976647

SN - 2079-6382

VL - 8

JO - Antibiotics

JF - Antibiotics

IS - 2

M1 - 43

ER -

Drug susceptibility testing and synergistic antibacterial activity of curcumin with antibiotics against enterotoxigenic Escherichia coli

Resumen

Nota bibliográfica

ODS de las Naciones Unidas

Acceder al documento

Huella

Citar esto