Cheiloclines A-I. First examples of octacyclic sesquiterpene-triterpene hetero-Diels-Alder adducts

Dulce Mesa-Siverio; Haydee Chávez; Ana Estévez-Braun; Ángel G. Ravelo

doi:10.1016/j.tet.2004.10.074

Cheiloclines A-I. First examples of octacyclic sesquiterpene-triterpene hetero-Diels-Alder adducts

Dulce Mesa-Siverio, Haydee Chávez, Ana Estévez-Braun, Ángel G. Ravelo

FARMACIA Y BIOQUIMICA

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

15 Citas (Scopus)

Resumen

Cheiloclines A-I (1-9) have been isolated from the root bark of Cheiloclinium hippocratioides (Celastraceae). They represent the first examples of hetero-Diels-Alder adducts between a nor-triterpenequinone and a sesquiterpene. Their structures were elucidated on the basis of spectral analysis, including homonuclear and heteronuclear correlation NMR experiments (COSY, ROESY, HSQC and HMBC). These compounds were tested for antitumoral, antibacterial and aldose reductase inhibitory activities.

Idioma original	Inglés
Páginas (desde-hasta)	429-436
Número de páginas	8
Publicación	Tetrahedron
Volumen	61
N.º	2
DOI	https://doi.org/10.1016/j.tet.2004.10.074
Estado	Publicada - 10 ene. 2005

Nota bibliográfica

Funding Information:
This work has been funded by the Spanish MCYT (SAF2003-04200-C02-02) and by the ICIC (Instituto Canario de Investigación del Cáncer). D.M.S. thanks Caja Canarias-ULL for a predoctoral fellowship.

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10.1016/j.tet.2004.10.074

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title = "Cheiloclines A-I. First examples of octacyclic sesquiterpene-triterpene hetero-Diels-Alder adducts",

abstract = "Cheiloclines A-I (1-9) have been isolated from the root bark of Cheiloclinium hippocratioides (Celastraceae). They represent the first examples of hetero-Diels-Alder adducts between a nor-triterpenequinone and a sesquiterpene. Their structures were elucidated on the basis of spectral analysis, including homonuclear and heteronuclear correlation NMR experiments (COSY, ROESY, HSQC and HMBC). These compounds were tested for antitumoral, antibacterial and aldose reductase inhibitory activities.",

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author = "Dulce Mesa-Siverio and Haydee Ch{\'a}vez and Ana Est{\'e}vez-Braun and Ravelo, {{\'A}ngel G.}",

note = "Funding Information: This work has been funded by the Spanish MCYT (SAF2003-04200-C02-02) and by the ICIC (Instituto Canario de Investigaci{\'o}n del C{\'a}ncer). D.M.S. thanks Caja Canarias-ULL for a predoctoral fellowship.",

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AU - Mesa-Siverio, Dulce

AU - Chávez, Haydee

AU - Estévez-Braun, Ana

AU - Ravelo, Ángel G.

N1 - Funding Information: This work has been funded by the Spanish MCYT (SAF2003-04200-C02-02) and by the ICIC (Instituto Canario de Investigación del Cáncer). D.M.S. thanks Caja Canarias-ULL for a predoctoral fellowship.

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N2 - Cheiloclines A-I (1-9) have been isolated from the root bark of Cheiloclinium hippocratioides (Celastraceae). They represent the first examples of hetero-Diels-Alder adducts between a nor-triterpenequinone and a sesquiterpene. Their structures were elucidated on the basis of spectral analysis, including homonuclear and heteronuclear correlation NMR experiments (COSY, ROESY, HSQC and HMBC). These compounds were tested for antitumoral, antibacterial and aldose reductase inhibitory activities.

AB - Cheiloclines A-I (1-9) have been isolated from the root bark of Cheiloclinium hippocratioides (Celastraceae). They represent the first examples of hetero-Diels-Alder adducts between a nor-triterpenequinone and a sesquiterpene. Their structures were elucidated on the basis of spectral analysis, including homonuclear and heteronuclear correlation NMR experiments (COSY, ROESY, HSQC and HMBC). These compounds were tested for antitumoral, antibacterial and aldose reductase inhibitory activities.

KW - Diels-Alder reaction

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KW - Terpenoids

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Cheiloclines A-I. First examples of octacyclic sesquiterpene-triterpene hetero-Diels-Alder adducts

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