Tanacetum Parthenium (L.) Sch Bip From Peru: Antioxidant Profile and The Antinociceptive Effect in An Experimental Model

Oscar Herrera-Calderon, Wilfredo Bulege-Gutiérrez, Luz Alexandra Javier-Silva, Melva Iparraguirre-Meza, Victor Guillermo Sanchez-Araujo, Elizabeth Julia Melgar-Merino, Johnny Aldo Tinco-Jayo, José Santiago Almeida-Galindo, Josefa Bertha Pari-Olarte

Research output: Contribution to journalArticlepeer-review


Background: Tanacetum parthenium (L.) Sch Bip known as "santa maría"(Asteraceae family) is used in Peru for inflammatory diseases and also in colic, stomachache, headaches, diarrhea, among other. Objective: The aim was to determine the antioxidant profile, and analgesic effect of ethanolic extract of flowers and leaves of T. parthenium Material and Methods: Leaves and flowers of T. parthenium were soaked in 96% ethanol and the obtained extract was analyzed using chemical reactions for identifying each secondary metabolite, 2,2-Diphenyl-1-picrylhydrazyl (DPPH) was used to determine the antioxidant capacity, and the antinociceptive effect was determined by using tail flick method. Results: Qualitative phytochemical study indicates the presence phenolic compounds, alkaloids, flavonoids, saponins and steroids in both extracts. In DPPH assay IC50 showed in leaves and flowers extract 452.10 ± 10.2 μg/mL and 270.70 ± 20.6 μg/mL respectively. The antinociceptive effect was better in leaves at doses 300 mg/ Kg than flower extract. Conclusions: The ethanolic extract of flowers of T. parthenium showed a high antioxidant activity and antinociceptive effect in mice.

Original languageEnglish
Pages (from-to)435-437
Number of pages3
JournalPharmacognosy Journal
Issue number3
StatePublished - May 2023

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  • Analgesic
  • Antioxidant
  • Medicinal plants
  • Polyphenols
  • Tanacetum parthenium


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