Over the past decades, several studies have shown that tumor-related somatic and germline alterations predicts tumor prognosis, drug response and toxicity. Latin American populations present a vast geno-phenotypic diversity due to the great interethnic and interracial mixing. This genetic flow leads to the appearance of complex characteristics that allow individuals to adapt to endemic environments, such as high altitude or extreme tropical weather. These genetic changes, most of them subtle and unexplored, could establish a mutational profile to develop new pharmacogenomic therapies specific for Latin American populations. In this review, we present the current status of research on somatic and germline alterations in Latin America compared to those found in Caucasian and Asian populations.
|Journal||International Journal of Molecular Sciences|
|State||Published - Jun 2017|
Bibliographical noteFunding Information:
We thank to the Latin American Society of Pharmacogenomics and Personalized Medicine (SOLFAGEM) by sponsoring this article (www.solfagem.org). This work was partly financed by the grant Fondecyt 1140434, Chile.
© 2017 by the authors. Licensee MDPI, Basel, Switzerland.
- Latin America
- Precision medicine
- Single nucleotide polymorphism