State of art of cancer pharmacogenomics in Latin American populations

Andrés López-Cortés, Santiago Guerrero, María Ana Redal, Angel Tito Alvarado, Luis Abel Quiñones

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Over the past decades, several studies have shown that tumor-related somatic and germline alterations predicts tumor prognosis, drug response and toxicity. Latin American populations present a vast geno-phenotypic diversity due to the great interethnic and interracial mixing. This genetic flow leads to the appearance of complex characteristics that allow individuals to adapt to endemic environments, such as high altitude or extreme tropical weather. These genetic changes, most of them subtle and unexplored, could establish a mutational profile to develop new pharmacogenomic therapies specific for Latin American populations. In this review, we present the current status of research on somatic and germline alterations in Latin America compared to those found in Caucasian and Asian populations.

Original languageEnglish
Article number639
JournalInternational Journal of Molecular Sciences
Volume18
Issue number6
DOIs
StatePublished - Jun 2017
Externally publishedYes

Bibliographical note

Funding Information:
We thank to the Latin American Society of Pharmacogenomics and Personalized Medicine (SOLFAGEM) by sponsoring this article (www.solfagem.org). This work was partly financed by the grant Fondecyt 1140434, Chile.

Publisher Copyright:
© 2017 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Cancer
  • Latin America
  • Pharmacogenetics
  • Pharmacogenomics
  • Precision medicine
  • Single nucleotide polymorphism

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