New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania

Paulino Delgado-Méndez; Nora Herrera; Haydee Chávez; Ana Estévez-Braun; Ángel G. Ravelo; Fernando Cortes; Santiago Castanys; Francisco Gamarro

doi:10.1016/j.bmc.2007.10.071

New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania

Paulino Delgado-Méndez
, Nora Herrera
, Haydee Chávez
, Ana Estévez-Braun
, Ángel G. Ravelo
, Fernando Cortes
, Santiago Castanys
, Francisco Gamarro

University of La Laguna
Hospital Universitario Nuestra Senora de Candelaria
Parque Tecnológico de Ciencias de la Salud

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Two new sesquiterpenes (1-2) and one new lupane triterpene (3) have been isolated from the roots of Maytenus apurimacensis. The novel β-dihydroagarofurans are the first sesquiterpenes with a basic polyhydroxy skeleton of 15-deoxyalatol and 4,15-dideoxyalatol that show high MDR reversing activity in the protozoan parasite Leishmania tropica.

Original language	English
Pages (from-to)	1425-1430
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/j.bmc.2007.10.071
State	Published - 1 Feb 2008

Keywords

Celastraceae
Dihydro-β-agarofuran sesquiterpenes
Leishmania
Lupanes
MDR
Maytenus
Terpenoids

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10.1016/j.bmc.2007.10.071

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title = "New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania",

abstract = "Two new sesquiterpenes (1-2) and one new lupane triterpene (3) have been isolated from the roots of Maytenus apurimacensis. The novel β-dihydroagarofurans are the first sesquiterpenes with a basic polyhydroxy skeleton of 15-deoxyalatol and 4,15-dideoxyalatol that show high MDR reversing activity in the protozoan parasite Leishmania tropica.",

keywords = "Celastraceae, Dihydro-β-agarofuran sesquiterpenes, Leishmania, Lupanes, MDR, Maytenus, Terpenoids",

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T1 - New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania

AU - Delgado-Méndez, Paulino

AU - Herrera, Nora

AU - Chávez, Haydee

AU - Estévez-Braun, Ana

AU - Ravelo, Ángel G.

AU - Cortes, Fernando

AU - Castanys, Santiago

AU - Gamarro, Francisco

PY - 2008/2/1

Y1 - 2008/2/1

N2 - Two new sesquiterpenes (1-2) and one new lupane triterpene (3) have been isolated from the roots of Maytenus apurimacensis. The novel β-dihydroagarofurans are the first sesquiterpenes with a basic polyhydroxy skeleton of 15-deoxyalatol and 4,15-dideoxyalatol that show high MDR reversing activity in the protozoan parasite Leishmania tropica.

AB - Two new sesquiterpenes (1-2) and one new lupane triterpene (3) have been isolated from the roots of Maytenus apurimacensis. The novel β-dihydroagarofurans are the first sesquiterpenes with a basic polyhydroxy skeleton of 15-deoxyalatol and 4,15-dideoxyalatol that show high MDR reversing activity in the protozoan parasite Leishmania tropica.

KW - Celastraceae

KW - Dihydro-β-agarofuran sesquiterpenes

KW - Leishmania

KW - Lupanes

KW - MDR

KW - Maytenus

KW - Terpenoids

UR - https://www.scopus.com/pages/publications/38849125592

U2 - 10.1016/j.bmc.2007.10.071

DO - 10.1016/j.bmc.2007.10.071

M3 - Artículo

C2 - 18035546

AN - SCOPUS:38849125592

SN - 0968-0896

VL - 16

SP - 1425

EP - 1430

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 3

ER -

New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania

Abstract

Keywords

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