New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania

Paulino Delgado-Méndez; Nora Herrera; Haydee Chávez; Ana Estévez-Braun; Ángel G. Ravelo; Fernando Cortes; Santiago Castanys; Francisco Gamarro

doi:10.1016/j.bmc.2007.10.071

New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania

Paulino Delgado-Méndez, Nora Herrera, Haydee Chávez, Ana Estévez-Braun, Ángel G. Ravelo, Fernando Cortes, Santiago Castanys, Francisco Gamarro

FARMACIA Y BIOQUIMICA

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Two new sesquiterpenes (1-2) and one new lupane triterpene (3) have been isolated from the roots of Maytenus apurimacensis. The novel β-dihydroagarofurans are the first sesquiterpenes with a basic polyhydroxy skeleton of 15-deoxyalatol and 4,15-dideoxyalatol that show high MDR reversing activity in the protozoan parasite Leishmania tropica.

Original language	English
Pages (from-to)	1425-1430
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/j.bmc.2007.10.071
State	Published - 1 Feb 2008

Bibliographical note

Funding Information:
This work has been supported by the MCYT (SAF-2003-04200-C02-01, Project SAF2006-66720,) by ICIC (Instituto Canario de Investigación del Cáncer), by RICET Project RD06/0021/0002 and by Plan Andaluz de Investigación (Cod. CVI-130). We also thank to Dr. Trujillo-Vásquez for carrying out the CD spectra. P.D.M. thanks the support of the Universidad de Los Andes Sabbatical Program.

Keywords

Celastraceae
Dihydro-β-agarofuran sesquiterpenes
Leishmania
Lupanes
MDR
Maytenus
Terpenoids

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title = "New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania",

abstract = "Two new sesquiterpenes (1-2) and one new lupane triterpene (3) have been isolated from the roots of Maytenus apurimacensis. The novel β-dihydroagarofurans are the first sesquiterpenes with a basic polyhydroxy skeleton of 15-deoxyalatol and 4,15-dideoxyalatol that show high MDR reversing activity in the protozoan parasite Leishmania tropica.",

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note = "Funding Information: This work has been supported by the MCYT (SAF-2003-04200-C02-01, Project SAF2006-66720,) by ICIC (Instituto Canario de Investigaci{\'o}n del C{\'a}ncer), by RICET Project RD06/0021/0002 and by Plan Andaluz de Investigaci{\'o}n (Cod. CVI-130). We also thank to Dr. Trujillo-V{\'a}squez for carrying out the CD spectra. P.D.M. thanks the support of the Universidad de Los Andes Sabbatical Program.",

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AU - Delgado-Méndez, Paulino

AU - Herrera, Nora

AU - Chávez, Haydee

AU - Estévez-Braun, Ana

AU - Ravelo, Ángel G.

AU - Cortes, Fernando

AU - Castanys, Santiago

AU - Gamarro, Francisco

N1 - Funding Information: This work has been supported by the MCYT (SAF-2003-04200-C02-01, Project SAF2006-66720,) by ICIC (Instituto Canario de Investigación del Cáncer), by RICET Project RD06/0021/0002 and by Plan Andaluz de Investigación (Cod. CVI-130). We also thank to Dr. Trujillo-Vásquez for carrying out the CD spectra. P.D.M. thanks the support of the Universidad de Los Andes Sabbatical Program.

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N2 - Two new sesquiterpenes (1-2) and one new lupane triterpene (3) have been isolated from the roots of Maytenus apurimacensis. The novel β-dihydroagarofurans are the first sesquiterpenes with a basic polyhydroxy skeleton of 15-deoxyalatol and 4,15-dideoxyalatol that show high MDR reversing activity in the protozoan parasite Leishmania tropica.

AB - Two new sesquiterpenes (1-2) and one new lupane triterpene (3) have been isolated from the roots of Maytenus apurimacensis. The novel β-dihydroagarofurans are the first sesquiterpenes with a basic polyhydroxy skeleton of 15-deoxyalatol and 4,15-dideoxyalatol that show high MDR reversing activity in the protozoan parasite Leishmania tropica.

KW - Celastraceae

KW - Dihydro-β-agarofuran sesquiterpenes

KW - Leishmania

KW - Lupanes

KW - MDR

KW - Maytenus

KW - Terpenoids

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JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

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ER -

New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania

Abstract

Bibliographical note

Keywords

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