New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania

Paulino Delgado-Méndez, Nora Herrera, Haydee Chávez, Ana Estévez-Braun, Ángel G. Ravelo, Fernando Cortes, Santiago Castanys, Francisco Gamarro

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Two new sesquiterpenes (1-2) and one new lupane triterpene (3) have been isolated from the roots of Maytenus apurimacensis. The novel β-dihydroagarofurans are the first sesquiterpenes with a basic polyhydroxy skeleton of 15-deoxyalatol and 4,15-dideoxyalatol that show high MDR reversing activity in the protozoan parasite Leishmania tropica.

Original languageEnglish
Pages (from-to)1425-1430
Number of pages6
JournalBioorganic and Medicinal Chemistry
Volume16
Issue number3
DOIs
StatePublished - 1 Feb 2008

Bibliographical note

Funding Information:
This work has been supported by the MCYT (SAF-2003-04200-C02-01, Project SAF2006-66720,) by ICIC (Instituto Canario de Investigación del Cáncer), by RICET Project RD06/0021/0002 and by Plan Andaluz de Investigación (Cod. CVI-130). We also thank to Dr. Trujillo-Vásquez for carrying out the CD spectra. P.D.M. thanks the support of the Universidad de Los Andes Sabbatical Program.

Keywords

  • Celastraceae
  • Dihydro-β-agarofuran sesquiterpenes
  • Leishmania
  • Lupanes
  • MDR
  • Maytenus
  • Terpenoids

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