Macrocarpins A-D, new cytotoxic nor-triterpenes from Maytenus macrocarpa

Haydee Chávez; Gladis Rodríguez; Ana Estévez-Braun; Ángel G. Ravelo; Rafael Estévez-Reyes; Antonio G. González; Jose L. Fdez-Puente; Dolores García-Grávalos

doi:10.1016/S0960-894X(00)00082-2

Macrocarpins A-D, new cytotoxic nor-triterpenes from Maytenus macrocarpa

Haydee Chávez
, Gladis Rodríguez
, Ana Estévez-Braun
, Ángel G. Ravelo
, Rafael Estévez-Reyes
, Antonio G. González
, Jose L. Fdez-Puente
, Dolores García-Grávalos

University of La Laguna
BIOMAR Microbial Technologies
PharmaMar S.A.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Macrocarpins A (1), B (2), C (3) and D (4), four new nor-triterpenes, have been isolated from the roots of Maytenus macrocarpa. The structures were established by spectroscopic examinations. Natural compounds 1, 2, 4 and the acetyl derivative 1a are cytotoxic against four tumoral cell lines with IC₅₀ values ranging between 0.4 and 5.2 μM. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	759-762
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	8
DOIs	https://doi.org/10.1016/S0960-894X(00)00082-2
State	Published - Apr 2000
Externally published	Yes

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10.1016/S0960-894X(00)00082-2

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title = "Macrocarpins A-D, new cytotoxic nor-triterpenes from Maytenus macrocarpa",

abstract = "Macrocarpins A (1), B (2), C (3) and D (4), four new nor-triterpenes, have been isolated from the roots of Maytenus macrocarpa. The structures were established by spectroscopic examinations. Natural compounds 1, 2, 4 and the acetyl derivative 1a are cytotoxic against four tumoral cell lines with IC50 values ranging between 0.4 and 5.2 μM. (C) 2000 Elsevier Science Ltd. All rights reserved.",

author = "Haydee Ch{\'a}vez and Gladis Rodr{\'i}guez and Ana Est{\'e}vez-Braun and Ravelo, \{{\'A}ngel G.\} and Rafael Est{\'e}vez-Reyes and Gonz{\'a}lez, \{Antonio G.\} and Fdez-Puente, \{Jose L.\} and Dolores Garc{\'i}a-Gr{\'a}valos",

year = "2000",

month = apr,

doi = "10.1016/S0960-894X(00)00082-2",

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volume = "10",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Macrocarpins A-D, new cytotoxic nor-triterpenes from Maytenus macrocarpa

AU - Chávez, Haydee

AU - Rodríguez, Gladis

AU - Estévez-Braun, Ana

AU - Ravelo, Ángel G.

AU - Estévez-Reyes, Rafael

AU - González, Antonio G.

AU - Fdez-Puente, Jose L.

AU - García-Grávalos, Dolores

PY - 2000/4

Y1 - 2000/4

N2 - Macrocarpins A (1), B (2), C (3) and D (4), four new nor-triterpenes, have been isolated from the roots of Maytenus macrocarpa. The structures were established by spectroscopic examinations. Natural compounds 1, 2, 4 and the acetyl derivative 1a are cytotoxic against four tumoral cell lines with IC50 values ranging between 0.4 and 5.2 μM. (C) 2000 Elsevier Science Ltd. All rights reserved.

AB - Macrocarpins A (1), B (2), C (3) and D (4), four new nor-triterpenes, have been isolated from the roots of Maytenus macrocarpa. The structures were established by spectroscopic examinations. Natural compounds 1, 2, 4 and the acetyl derivative 1a are cytotoxic against four tumoral cell lines with IC50 values ranging between 0.4 and 5.2 μM. (C) 2000 Elsevier Science Ltd. All rights reserved.

UR - https://www.scopus.com/pages/publications/0242689810

U2 - 10.1016/S0960-894X(00)00082-2

DO - 10.1016/S0960-894X(00)00082-2

M3 - Artículo

C2 - 10782680

AN - SCOPUS:0242689810

SN - 0960-894X

VL - 10

SP - 759

EP - 762

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 8

ER -

Macrocarpins A-D, new cytotoxic nor-triterpenes from Maytenus macrocarpa

Abstract

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