Macrocarpins A-D, new cytotoxic nor-triterpenes from Maytenus macrocarpa

Haydee Chávez, Gladis Rodríguez, Ana Estévez-Braun, Ángel G. Ravelo, Rafael Estévez-Reyes, Antonio G. González, Jose L. Fdez-Puente, Dolores García-Grávalos

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24 Scopus citations


Macrocarpins A (1), B (2), C (3) and D (4), four new nor-triterpenes, have been isolated from the roots of Maytenus macrocarpa. The structures were established by spectroscopic examinations. Natural compounds 1, 2, 4 and the acetyl derivative 1a are cytotoxic against four tumoral cell lines with IC50 values ranging between 0.4 and 5.2 μM. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)759-762
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number8
StatePublished - Apr 2000
Externally publishedYes

Bibliographical note

Funding Information:
This work has been partly funded by the Spanish DGES (projects PB 96-1033 and PB 96-10339, by the Gobierno Autónomo de Canarias, and by the Instituto Tecnológico de Canarias. H. Chávez thanks the Agencia Española de Cooperación Internacional for a MUTIS grant. Thanks are also due to Professor L. Ruı́z for gathering the plant.


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