Macrocarpins A (1), B (2), C (3) and D (4), four new nor-triterpenes, have been isolated from the roots of Maytenus macrocarpa. The structures were established by spectroscopic examinations. Natural compounds 1, 2, 4 and the acetyl derivative 1a are cytotoxic against four tumoral cell lines with IC50 values ranging between 0.4 and 5.2 μM. (C) 2000 Elsevier Science Ltd. All rights reserved.
Bibliographical noteFunding Information:
This work has been partly funded by the Spanish DGES (projects PB 96-1033 and PB 96-10339, by the Gobierno Autónomo de Canarias, and by the Instituto Tecnológico de Canarias. H. Chávez thanks the Agencia Española de Cooperación Internacional for a MUTIS grant. Thanks are also due to Professor L. Ruı́z for gathering the plant.