Identification of a novel potassium channel (GiK) as a potential drug target in Giardia lamblia: Computational descriptions of binding sites

Keyphrases

• Giardia Lamblia 100%
• Binding Site 100%
• Putative Drug Targets 100%
• Potassium Channel 100%
• Potassium Channel Blockers 50%
• Potassium 25%
• Diarrheal Disease 25%
• Drug Resistance 25%
• In Silico 25%
• Causal Agent 25%
• High Affinity 25%
• Treatment Failure 25%
• Giardiasis 25%
• Molecular Targets 25%
• Antigiardial Drugs 25%
• Virtual Screening 25%
• Antigiardial 25%
• Quality Validation 25%
• Drug Design 25%
• Homology Modeling 25%
• Good Target 25%
• Three Dimensional Model 25%
• Growth Response 25%
• Validation Parameters 25%
• Biological Testing 25%
• Protein-protein Docking 25%
• Protozoa 25%
• Modeled Structure 25%
• Quality Assessment Parameters 25%
• Target-based Drug Design 25%
• Crystalline Structure 25%
• Structure-based Drug Design 25%
• Pore Domain 25%
• Screening Approach 25%
• SKCa 25%
• SK Channels 25%
• Beta-blockers 25%
• Design Study 25%
• Signature Sequence 25%
• Stress Response 25%
• Ionic Channels 25%
• New Targets 25%
• Promising Target 25%
• Giardia Infection 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Giardia intestinalis 100%
• Binding Site 100%
• Potassium Channel 100%
• Protozoon 50%
• Giardiasis 50%
• Potassium Channel Blocking Agent 50%
• Drug Development 50%
• Infection 25%
• Drug Resistance 25%
• Virtual Screening 25%
• Isotopes of Potassium 25%
• Protein Ligand 25%
• Small Conductance Calcium Activated Potassium Channel 25%
• Ion Channel 25%
• Docking Protein 25%
• Molecular Target 25%

Biochemistry, Genetics and Molecular Biology

• Binding Site 100%
• Giardia intestinalis 100%
• Potassium Channel 100%
• Protozoon 50%
• Life Cycle 50%
• Potassium Channel Blocker 50%
• Drug Resistance 25%
• Giardia 25%
• Life Stress 25%
• Ion Channel 25%
• Protein-Ligand Docking 25%
• Homology Modeling 25%
• SK Channel 25%