Frequency of CYP1A1*2A polymorphisms and deletion of the GSMT1 gene in a Peruvian mestizo population

Angel Tito Alvarado; Ana María Muñoz; María Saravia Bartra; Milton Valderrama-Wong; Daniela González; Luis Abel Quiñones; Nelson Varela; María Rocío Bendezú; Jorge Antonio García; Berta Loja-Herrera

doi:10.3897/pharmacia.68.e71621

Frequency of CYP1A1*2A polymorphisms and deletion of the GSMT1 gene in a Peruvian mestizo population

Angel Tito Alvarado, Ana María Muñoz, María Saravia Bartra, Milton Valderrama-Wong, Daniela González, Luis Abel Quiñones, Nelson Varela, María Rocío Bendezú, Jorge Antonio García, Berta Loja-Herrera

FARMACIA Y BIOQUIMICA

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The polymorphic variants of CYP1A1 and the deletion of GSTM1 are present in the Peruvian mestizo population. Wild type and mutated genotypes (WT/*2A and *2A/*2A) were identified, whose allele frequencies are 0.31 (T allele) and 0.69 (C allele), respectively; 53% with wild type GSTM1 (+) and 47% with null GSTM1. The frequency in Iquiteño emigrants was 0.72 CYP1A1*2A and 25% GSTM1 (-); from Lima 0.67 CYP1A1*2A and 33% of GSTM1 (-). The Hardy-Weinberg equilibrium test for the studied population showed that both frequencies are out of balance, p > .05. The presence of the risk allele of the CYP1A1*2A polymorphism and the deletion in the GSTM1 gene are high, which could be indicative of a phase I and II metabolic imbalance in this group of Peruvian populations, with potential risks of activating agents procarcinogens thus affecting the incidence of tumor pathologies with an environmental component.

Original language	English
Pages (from-to)	747-754
Number of pages	8
Journal	Pharmacia
Volume	68
Issue number	4
DOIs	https://doi.org/10.3897/pharmacia.68.e71621
State	Published - 2021

Bibliographical note

Publisher Copyright:
© 2021. Alvarado AT et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Keywords

Allelic variants
Mestizo
Mutagens
Peru
Procarcinogens

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10.3897/pharmacia.68.e71621

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title = "Frequency of CYP1A1*2A polymorphisms and deletion of the GSMT1 gene in a Peruvian mestizo population",

abstract = "The polymorphic variants of CYP1A1 and the deletion of GSTM1 are present in the Peruvian mestizo population. Wild type and mutated genotypes (WT/*2A and *2A/*2A) were identified, whose allele frequencies are 0.31 (T allele) and 0.69 (C allele), respectively; 53% with wild type GSTM1 (+) and 47% with null GSTM1. The frequency in Iquite{\~n}o emigrants was 0.72 CYP1A1*2A and 25% GSTM1 (-); from Lima 0.67 CYP1A1*2A and 33% of GSTM1 (-). The Hardy-Weinberg equilibrium test for the studied population showed that both frequencies are out of balance, p > .05. The presence of the risk allele of the CYP1A1*2A polymorphism and the deletion in the GSTM1 gene are high, which could be indicative of a phase I and II metabolic imbalance in this group of Peruvian populations, with potential risks of activating agents procarcinogens thus affecting the incidence of tumor pathologies with an environmental component.",

keywords = "Allelic variants, Mestizo, Mutagens, Peru, Procarcinogens",

author = "Alvarado, {Angel Tito} and Mu{\~n}oz, {Ana Mar{\'i}a} and Bartra, {Mar{\'i}a Saravia} and Milton Valderrama-Wong and Daniela Gonz{\'a}lez and Qui{\~n}ones, {Luis Abel} and Nelson Varela and Bendez{\'u}, {Mar{\'i}a Roc{\'i}o} and Garc{\'i}a, {Jorge Antonio} and Berta Loja-Herrera",

note = "Publisher Copyright: {\textcopyright} 2021. Alvarado AT et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

year = "2021",

doi = "10.3897/pharmacia.68.e71621",

language = "Ingl{\'e}s",

volume = "68",

pages = "747--754",

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TY - JOUR

T1 - Frequency of CYP1A1*2A polymorphisms and deletion of the GSMT1 gene in a Peruvian mestizo population

AU - Alvarado, Angel Tito

AU - Muñoz, Ana María

AU - Bartra, María Saravia

AU - Valderrama-Wong, Milton

AU - González, Daniela

AU - Quiñones, Luis Abel

AU - Varela, Nelson

AU - Bendezú, María Rocío

AU - García, Jorge Antonio

AU - Loja-Herrera, Berta

N1 - Publisher Copyright: © 2021. Alvarado AT et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2021

Y1 - 2021

N2 - The polymorphic variants of CYP1A1 and the deletion of GSTM1 are present in the Peruvian mestizo population. Wild type and mutated genotypes (WT/*2A and *2A/*2A) were identified, whose allele frequencies are 0.31 (T allele) and 0.69 (C allele), respectively; 53% with wild type GSTM1 (+) and 47% with null GSTM1. The frequency in Iquiteño emigrants was 0.72 CYP1A1*2A and 25% GSTM1 (-); from Lima 0.67 CYP1A1*2A and 33% of GSTM1 (-). The Hardy-Weinberg equilibrium test for the studied population showed that both frequencies are out of balance, p > .05. The presence of the risk allele of the CYP1A1*2A polymorphism and the deletion in the GSTM1 gene are high, which could be indicative of a phase I and II metabolic imbalance in this group of Peruvian populations, with potential risks of activating agents procarcinogens thus affecting the incidence of tumor pathologies with an environmental component.

AB - The polymorphic variants of CYP1A1 and the deletion of GSTM1 are present in the Peruvian mestizo population. Wild type and mutated genotypes (WT/*2A and *2A/*2A) were identified, whose allele frequencies are 0.31 (T allele) and 0.69 (C allele), respectively; 53% with wild type GSTM1 (+) and 47% with null GSTM1. The frequency in Iquiteño emigrants was 0.72 CYP1A1*2A and 25% GSTM1 (-); from Lima 0.67 CYP1A1*2A and 33% of GSTM1 (-). The Hardy-Weinberg equilibrium test for the studied population showed that both frequencies are out of balance, p > .05. The presence of the risk allele of the CYP1A1*2A polymorphism and the deletion in the GSTM1 gene are high, which could be indicative of a phase I and II metabolic imbalance in this group of Peruvian populations, with potential risks of activating agents procarcinogens thus affecting the incidence of tumor pathologies with an environmental component.

KW - Allelic variants

KW - Mestizo

KW - Mutagens

KW - Peru

KW - Procarcinogens

UR - http://www.scopus.com/inward/record.url?scp=85117952982&partnerID=8YFLogxK

U2 - 10.3897/pharmacia.68.e71621

DO - 10.3897/pharmacia.68.e71621

M3 - Artículo

AN - SCOPUS:85117952982

SN - 0428-0296

VL - 68

SP - 747

EP - 754

JO - Pharmacia

JF - Pharmacia

IS - 4

ER -

Frequency of CYP1A1*2A polymorphisms and deletion of the GSMT1 gene in a Peruvian mestizo population

Abstract

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Keywords

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