TY - JOUR
T1 - Effect of telmisartan in the oxidative stress components induced by ischemia reperfusion in rats
AU - Rodríguez-Lara, Simón Quetzalcoatl
AU - Trujillo-Rangel, Walter Angel
AU - Castillo-Romero, Araceli
AU - Totsuka-Sutto, Sylvia Elena
AU - Garcia-Cobián, Teresa Arcelia
AU - Cardona-Muñoz, Ernesto German
AU - Miranda-DÍaz, Alejandra Guillermina
AU - Ramírez-Lizardo, Ernesto Javier
AU - García-Benavides, Leonel
N1 - Publisher Copyright:
© 2019 Simón Quetzalcoatl Rodríguez-Lara et al.
PY - 2019
Y1 - 2019
N2 - The therapeutic effects of telmisartan, an angiotensin II receptor antagonist and a peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, have been demonstrated in several disorders. It has antioxidant and immune response modulator properties and has shown promising results in the treatment of an ischemia/reperfusion (I/R) lesion. In this study, a skeletal muscle (right gastrocnemius muscle) I/R lesion was induced in rats and different reperfusion times (1 h, 24 h, 72 h, 7-day, and 14-day subgroups) were assessed. Furthermore, levels of oxidative markers such as enzymatic scavengers (catalase (CAT) and superoxide dismutase (SOD)) and metabolites (nitrates and 8-oxo-deoxyguanosine) were determined. The degree of tissue injury (total lesioned fibers and inflammatory cell count) was also evaluated. We observed an increase in CAT and SOD expression levels under telmisartan treatment, with a decrease in injury and oxidative biomarker levels in the 72 h, 7-day, and 14-day subgroups. Telmisartan reduced oxidative stress and decreased the damage of the I/R lesion.
AB - The therapeutic effects of telmisartan, an angiotensin II receptor antagonist and a peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, have been demonstrated in several disorders. It has antioxidant and immune response modulator properties and has shown promising results in the treatment of an ischemia/reperfusion (I/R) lesion. In this study, a skeletal muscle (right gastrocnemius muscle) I/R lesion was induced in rats and different reperfusion times (1 h, 24 h, 72 h, 7-day, and 14-day subgroups) were assessed. Furthermore, levels of oxidative markers such as enzymatic scavengers (catalase (CAT) and superoxide dismutase (SOD)) and metabolites (nitrates and 8-oxo-deoxyguanosine) were determined. The degree of tissue injury (total lesioned fibers and inflammatory cell count) was also evaluated. We observed an increase in CAT and SOD expression levels under telmisartan treatment, with a decrease in injury and oxidative biomarker levels in the 72 h, 7-day, and 14-day subgroups. Telmisartan reduced oxidative stress and decreased the damage of the I/R lesion.
UR - http://www.scopus.com/inward/record.url?scp=85070699003&partnerID=8YFLogxK
U2 - 10.1155/2019/1302985
DO - 10.1155/2019/1302985
M3 - Artículo
C2 - 31354899
AN - SCOPUS:85070699003
SN - 1942-0900
VL - 2019
JO - Oxidative Medicine and Cellular Longevity
JF - Oxidative Medicine and Cellular Longevity
M1 - 1302985
ER -