Effect of the alkaloid extract from Jatropha curcas L. seeds on the intestinal motility

Translated title of the contribution: Effect of the alkaloid extract from Jatropha curcas L. seeds on the intestinal motility

José María Carrasco Rueda, Armando Fartolino Guerrero, Ángela Sánchez Chávez, Junior Lujan Reyes, Alessandra Pachas Quiroz, Lucía del Carmen Castilla Candela, Rodrigo Núñez Bravo, Karen Osorio Giraldi, Ángel Alvarado Yarasca, C. Berta Loja Herrera, Alberto Salazar Granara

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Introduction: preclinical research studies of Jatropha curcas L. (piñón blanco) root extract proved its antidiarrheal activity; however the chronic toxicity test of the total seed extract demonstrated diarrheal effect. Objectives: to determine the effect of the alkaloid extract from Jatropha curcas L. seeds on the gastrointestinal motility. Methods: fifty albino mice with average weight of 25 g were used. The Arbos et al. ́s method was applied. The intestinal marker was 5 % activated charcoal administered at a dose of 0.1 mL/10 g. The experimental groups included 0.1 mL/10 g of distilled water, 1.5 mg/kg of atropine, alkaloid extract of Jatropha curcas L. seeds at doses of 500 and 1 000 mg/kg respectively, and 1 g/kg of neostigmine The statistical validation was based on Kruskal-Wallis test, ANOVA, and Tukey and Newman-Keuls test. Results: the percentages of the charcoal run were 69.21, 36.37, 58.96, 49.65, and 74.17 respectively. The ANOVA test demonstrated statistical significance (p< 0.05, IC 95 %). Comparative Tukey and Newman-Keuls test showed statistical significance between distilled water and Jatropha curcas at a dose of 1 000 mg/kg. Conclusions: the decrease on the gastrointestinal motility resulting from the effect of the alkaloid extract of Jatropha curcas seeds was proved at a dose of 1 000 mg/kg.

Translated title of the contributionEffect of the alkaloid extract from Jatropha curcas L. seeds on the intestinal motility
Original languageEnglish
Pages (from-to)84-91
Number of pages8
JournalRevista Cubana de Plantas Medicinales
Volume18
Issue number1
StatePublished - 2013
Externally publishedYes

Keywords

  • Alkaloid
  • Intestinal motility
  • Jatropha curcas L.

Fingerprint

Dive into the research topics of 'Effect of the alkaloid extract from Jatropha curcas L. seeds on the intestinal motility'. Together they form a unique fingerprint.

Cite this