Cytotoxic triterpenoids from Maytenus retusa

Sandra M. Oramas-Royo; Haydee Chávez; Patricia Martín-Rodríguez; Leandro Fernández-Pérez; Ángel G. Ravelo; Ana Estévez-Braun

doi:10.1021/np100517u

Cytotoxic triterpenoids from Maytenus retusa

Sandra M. Oramas-Royo, Haydee Chávez, Patricia Martín-Rodríguez, Leandro Fernández-Pérez, Ángel G. Ravelo, Ana Estévez-Braun

FARMACIA Y BIOQUIMICA

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28 Scopus citations

Abstract

Seven new triterpenoids (1-7) and 36 known compounds were isolated from the root bark of Maytenus retusa. Their structures were determined by 1D and 2D spectroscopic studies. Several compounds were evaluated for their cytotoxicity against the human tumor cell lines HL-60 and MCF-7. Some of them were cytotoxic, with IC₅₀ values ranging between 0.2 and 4.7 μM.

Original language	English
Pages (from-to)	2029-2034
Number of pages	6
Journal	Journal of Natural Products
Volume	73
Issue number	12
DOIs	https://doi.org/10.1021/np100517u
State	Published - 27 Dec 2010

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abstract = "Seven new triterpenoids (1-7) and 36 known compounds were isolated from the root bark of Maytenus retusa. Their structures were determined by 1D and 2D spectroscopic studies. Several compounds were evaluated for their cytotoxicity against the human tumor cell lines HL-60 and MCF-7. Some of them were cytotoxic, with IC50 values ranging between 0.2 and 4.7 μM.",

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AU - Fernández-Pérez, Leandro

AU - Ravelo, Ángel G.

AU - Estévez-Braun, Ana

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AB - Seven new triterpenoids (1-7) and 36 known compounds were isolated from the root bark of Maytenus retusa. Their structures were determined by 1D and 2D spectroscopic studies. Several compounds were evaluated for their cytotoxicity against the human tumor cell lines HL-60 and MCF-7. Some of them were cytotoxic, with IC50 values ranging between 0.2 and 4.7 μM.

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Cytotoxic triterpenoids from Maytenus retusa

Abstract

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