The synthesis of novel pyrano embelin derivatives has been achieved through domino Knoevenagel hetero Diels-Alder reactions of embelin (1) with paraformaldehyde and electron rich alkenes. This synthetic approach is highly efficient when microwave irradiation is used.
Bibliographical noteFunding Information:
This work has been funded by the Spanish MCYT (SAF2006-06720) and by ICIC. S.J.-A. thanks the MCYT for a predoctoral fellowship. We thank Dr. García-Tellado for granting access to the microwave apparatus.
- Knoevenagel heteroDiels-Alderreactions
- Multicomponent reactions
- MW irradiation