An efficient synthesis of embelin derivatives through domino Knoevenagel hetero Diels-Alder reactions under microwave irradiation

Sandra Jiménez-Alonso, Haydee Chávez, Ana Estévez-Braun, Ángel G. Ravelo, Gabriela Feresin, Alejandro Tapia

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56 Scopus citations

Abstract

The synthesis of novel pyrano embelin derivatives has been achieved through domino Knoevenagel hetero Diels-Alder reactions of embelin (1) with paraformaldehyde and electron rich alkenes. This synthetic approach is highly efficient when microwave irradiation is used.

Original languageEnglish
Pages (from-to)8938-8942
Number of pages5
JournalTetrahedron
Volume64
Issue number37
DOIs
StatePublished - 8 Sep 2008

Bibliographical note

Funding Information:
This work has been funded by the Spanish MCYT (SAF2006-06720) and by ICIC. S.J.-A. thanks the MCYT for a predoctoral fellowship. We thank Dr. García-Tellado for granting access to the microwave apparatus.

Keywords

  • Knoevenagel heteroDiels-Alderreactions
  • MW irradiation
  • Multicomponent reactions
  • Quinones

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