TY - JOUR
T1 - Albendazole and its derivative JVG9 induce encystation on Giardia intestinalis trophozoites
AU - Pérez-Rangel, Armando
AU - Hernández, José Manuel
AU - Castillo-Romero, Araceli
AU - Yépez-Mulia, Lilián
AU - Castillo, Rafael
AU - Hernández-Luis, Francisco
AU - Nogueda-Torres, Benjamín
AU - Luna-Arias, Juan Pedro
AU - Radilla, Gerardo
AU - León-Avila, Gloria
PY - 2013/9
Y1 - 2013/9
N2 - In the present study, we evaluated the effect of an albendazole (ABZ) derivative JVG9 on cultured Giardia intestinalis. To assess the JVG9 effects, we evaluated the tubulin cytoskeleton by confocal microscopy, and we found that the characteristic staining was modified. The scanning electron microscopy images revealed extremely damaged trophozoites and cyst-like cells. The confocal images revealed that this drug triggered the expression of cyst wall protein 1 and encystation. We also found that at low doses, AL triggered the encystation process too.
AB - In the present study, we evaluated the effect of an albendazole (ABZ) derivative JVG9 on cultured Giardia intestinalis. To assess the JVG9 effects, we evaluated the tubulin cytoskeleton by confocal microscopy, and we found that the characteristic staining was modified. The scanning electron microscopy images revealed extremely damaged trophozoites and cyst-like cells. The confocal images revealed that this drug triggered the expression of cyst wall protein 1 and encystation. We also found that at low doses, AL triggered the encystation process too.
UR - http://www.scopus.com/inward/record.url?scp=84882731006&partnerID=8YFLogxK
U2 - 10.1007/s00436-013-3521-1
DO - 10.1007/s00436-013-3521-1
M3 - Artículo
C2 - 23857298
AN - SCOPUS:84882731006
SN - 0932-0113
VL - 112
SP - 3251
EP - 3257
JO - Parasitology Research
JF - Parasitology Research
IS - 9
ER -
