Activity of Lepidium meyenii Walp (purple maca) in immunosuppressed Oryctolagus cuniculus (albino rabbits)

Angel T. Alvarado, Carlos Navarro, Mario Pineda, Laura Villanueva, Ana María Muñoz, María R. Bendezú, Haydee Chávez, Jorge A. García

Research output: Contribution to journalArticlepeer-review

Abstract

Various properties are attributed to “maca”, including immunomodulatory properties due to its secondary metabolites such as macamides, glucosinolates, isothiocyanates and flavonoids. Immunosuppression, hemolytic anemia, and thymic involution were induced with cyclophosphamide. Three concentrations of doses of dehydrated hydroalcoholic extract of purple maca (EHADM) were used for 30 days, the analysis of variance and Duncan's multiple comparisons test the results are statistically significant (p<.05) which shows immunostimulatory activity in the marrow bone (monocytes, lymphocytes and white blood cells) and antianemic (hematocrit 31%) compared to the negative control group (G-1). At 84 mg/kg and at 167 mg/kg, it shows immunomodulatory activity on the humoral response in 66.70% of the experimental animals (G-3 and G-4). It is concluded that the dehydrated hydroalcoholic extract of purple maca presents immunostimulating and immunomodulatory activity on the humoral response in 66.7% of the Oryctolagus cuniculus induced to immunodeficiency with cyclophosphamide.

Original languageEnglish
Pages (from-to)501-507
Number of pages7
JournalPharmacia
Volume69
Issue number2
DOIs
StatePublished - 2022

Bibliographical note

Funding Information:
Peruvian Association of Immunogenomics and Personalized Medicine; Molecular Pharmacology Society of Peru.

Publisher Copyright:
© 2022. Alvarado AT et al. All Rights Reserved.

Keywords

  • Ecotype
  • immunosuppression
  • macamides
  • purple maca

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